# Eun-Kyung Lee

#### 9 packages on CRAN

#### 1 packages on Bioconductor

The visual predictive checks are well-known method to validate the nonlinear mixed effect model, especially in pharmacometrics area. The average shifted visual predictive checks are the newly developed method of Visual predictive checks combined with the idea of the average shifted histogram.

Provides the analysis of variance table including the expected mean squares (EMS) for various types of experimental design. When some variables are random effects or we use special experimental design such as nested design, repeated-measures design, or split-plot design, it is not easy to find the appropriate test, especially denominator for F-statistic which depends on EMS.

Pharmacokinetics is the study of drug absorption, distribution, metabolism, and excretion. The pharmacokinetics model explains that how the drug concentration change as the drug moves through the different compartments of the body. For pharmacokinetic modeling and analysis, it is essential to understand the basic pharmacokinetic parameters. All parameters are considered, but only some of parameters are used in the model. Therefore, we need to convert the estimated parameters to the other parameters after fitting the specific pharmacokinetic model. This package is developed to help this converting work. For more detailed explanation of pharmacokinetic parameters, see "Gabrielsson and Weiner" (2007), "ISBN-10: 9197651001"; "Benet and Zia-Amirhosseini" (1995) <DOI: 10.1177/019262339502300203>; "Mould and Upton" (2012) <doi:10.1038/psp.2012.4>; "Mould and Upton" (2013) <doi:10.1038/psp.2013.14>.

Tools for exploring projection pursuit classification tree using various projection pursuit indexes.

Odds ratio based multifactor-dimensionality reduction method for detecting gene-gene interactions

This package is for the comparison of various types of A+B escalation rules for dose finding trials.