5 packages on CRAN
Perform association tests using generalized linear mixed models (GLMMs) in genome-wide association studies (GWAS) and sequencing association studies. First, GMMAT fits a GLMM with covariate adjustment and random effects to account for population structure and familial or cryptic relatedness. For GWAS, GMMAT performs score tests for each genetic variant as proposed in Chen et al. (2016) <DOI:10.1016/j.ajhg.2016.02.012>. For candidate gene studies, GMMAT can also perform Wald tests to get the effect size estimate for each genetic variant. For rare variant analysis from sequencing association studies, GMMAT performs the variant Set Mixed Model Association Tests (SMMAT) as proposed in Chen et al. (2019) <DOI:10.1016/j.ajhg.2018.12.012>, including the burden test, the sequence kernel association test (SKAT), SKAT-O and an efficient hybrid test of the burden test and SKAT, based on user-defined variant sets.
This package contains functions to run fixed effects or random effects multivariate meta-analysis.
Tests gene-environment interaction for rare genetic variants using Sequence Kernel Association Test (SKAT) type gene-based tests. Includes two tests for the interaction term only, and one joint test for genetic main effects and gene-environment interaction.
Tests gene-environment interaction for rare genetic variants within the framework of adaptive sum of powered score test. The package includes two tests: adaptive gene-by-environment interaction test, and joint test for genetic main effects and gene-environment interaction. See Yang et al (2018) <doi:10.1002/sim.8037>.
Computes necessary information to meta analyze region-based tests for rare genetic variants (e.g. SKAT, T1) in individual studies, and performs meta analysis.