# Vito MR Muggeo

#### 5 packages on CRAN

Estimation of number and location of change points in mean-shift (piecewise constant) models. Particularly useful to model genomic sequences of continuous measurements.

Functions to fits simple linear regression models with log normal errors and identity link (taking the responses on the original scale). See Muggeo (2018) <doi:10.13140/RG.2.2.18118.16965>.

Fits a Constrained Segmented Distributed Lag regression model to epidemiological time series of mortality, temperature, and other confounders.

Fits non-crossing regression quantiles as a function of linear covariates and multiple smooth terms via B-splines with L1-norm difference penalties. Monotonicity constraints on the fitted curves are allowed. See Muggeo, Sciandra, Tomasello and Calvo (2013) <doi:10.1007/s10651-012-0232-1> and <doi:10.13140/RG.2.2.12924.85122> for some code example.

Given a regression model, segmented `updates' it by adding one or more segmented (i.e., piece-wise linear) relationships. Several variables with multiple breakpoints are allowed. The estimation method is discussed in Muggeo (2003, <doi:10.1002/sim.1545>) and illustrated in Muggeo (2008, <https://www.r-project.org/doc/Rnews/Rnews_2008-1.pdf>). An approach for hypothesis testing is presented in Muggeo (2016, <doi:10.1080/00949655.2016.1149855>), and interval estimation for the breakpoint is discussed in Muggeo (2017, <doi:10.1111/anzs.12200>).