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aroma.affymetrix (version 2.5.0)

MbeiPlm: The MbeiPlm class

Description

Package: aroma.affymetrix Class MbeiPlm Object ~~| ~~+--Model ~~~~~~~| ~~~~~~~+--UnitModel ~~~~~~~~~~~~| ~~~~~~~~~~~~+--MultiArrayUnitModel ~~~~~~~~~~~~~~~~~| ~~~~~~~~~~~~~~~~~+--ProbeLevelModel ~~~~~~~~~~~~~~~~~~~~~~| ~~~~~~~~~~~~~~~~~~~~~~+--MbeiPlm Directly known subclasses: MbeiCnPlm, MbeiSnpPlm public static class MbeiPlm extends ProbeLevelModel This class represents the model-based expression indexes (MBEI) multiplicative model in Li & Wong (2001).

Usage

MbeiPlm(...)

Arguments

...
Arguments passed to ProbeLevelModel.

Fields and Methods

Methods: rll{ getAsteriskTags - } Methods inherited from ProbeLevelModel: calculateResidualSet, calculateWeights, fit, getAsteriskTags, getCalculateResidualsFunction, getChipEffectSet, getProbeAffinityFile, getResidualSet, getWeightsSet Methods inherited from MultiArrayUnitModel: getListOfPriors, setListOfPriors, validate Methods inherited from UnitModel: findUnitsTodo, getAsteriskTags, getFitSingleCellUnitFunction Methods inherited from Model: fit, getAlias, getAsteriskTags, getDataSet, getFullName, getName, getPath, getRootPath, getTags, setAlias, setTags Methods inherited from Object: asThis, getChecksum, $, $<-, [[, [[<-, as.character, attach, attachLocally, clearCache, clearLookupCache, clone, detach, equals, extend, finalize, gc, getEnvironment, getFieldModifier, getFieldModifiers, getFields, getInstantiationTime, getStaticInstance, hasField, hashCode, ll, load, objectSize, print, registerFinalizer, save

Model

For a single unit group, the multiplicative model is: $$y_{ik} = \theta_i \phi_k + \varepsilon_{ik}$$ where $\theta_i$ are the chip effects for arrays $i=1,...,I$, and $\phi_k$ are the probe affinities for probes $k=1,...,K$. The $\varepsilon_{ik}$ are zero-mean noise with equal variance. To make to parameters identifiable, the constraint $\prod_k \phi_k = 1$ is added.

References

Li, C. and Wong, W.H. (2001), Genome Biology 2, 1-11. Li, C. and Wong, W.H. (2001), Proc. Natl. Acad. Sci USA 98, 31-36.

See Also

Internally fit.li.wong is used.