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PSM (version 0.8-6)

PSM-package: Population Stochastic Modelling

Description

Mixed-effects models using Stochastic Differential Equations This package provides functions for estimation and simulation of multivariate linear and non-linear mixed-effects models using stochastic differential equations. The package allows for multidimensional input, specification of dosage regimen and is able to return smoothed estimates of model states.

Arguments

Details

Function overview: PSM.estimate Estimate population parameters for any linear or non-linear model. PSM.smooth Optimal estimates of model states based on estimated parameters. PSM.simulate Simulate data for multiple individuals.

PSM.plot Plot data, state estimates ect. for multiple individuals.

PSM.template Creates a template with R-syntax to help setup a model in PSM.

References

Stig B. Mortensen, S�ren Klim, Bernd Dammann, Niels R. Kristensen, Henrik Madsen, Rune V. Overgaard. A matlab framework for estimation of NLME models using stochastic differential equations: Application for estimation of insulin secretion rates. J Pharmacokinet Pharmacodyn (2007) 34:623-642.

Web: http://www.imm.dtu.dk/psm

See Also

PSM.estimate, PSM.smooth, PSM.simulate, PSM.plot, PSM.template