MBttest (version 1.0.0)

betaparametw: Estimation of Weights of Proportions

Description

Function betaparametw is used to calculate weight.

Usage

betaparametw(xn, a, b)

Arguments

xn

vector of m library sizes. Library size is sum of counts over the whole library.

a

parameter alpha in beta distribution derived from output of function Bag_parametab

b

parameter beta in beta distribution derived from output of function Bag_parametab

Value

return weight(W)

Details

alpha and beta are used to calculate weight. Then weight is in turn used to correct bias of estimation of alpha and beta in Bag_parametab function.

References

Baggerly KA, Deng L, Morris JS, Aldaz CM (2003) Differential expression in SAGE: accounting for normal between-library variation. Bioinformatics, 19: 1477-1483. \ Yuan-De Tan, Anita M. Chandler, Arindam Chaudhury, and Joel R. Neilson(2015) A Powerful Statistical Approach for Large-scale Differential Transcription Analysis.Plos One. 2015 DOI: 10.1371/journal.pone.0123658.

See Also

betaparametab,betaparametVP.

Examples

XX<-c(2000,2000,2000)
a<-1.1458
b<-6.4932
betaparametw(xn=XX,a=a,b=b)
#[1] 0.3333333 0.3333333 0.3333333