deSolve (version 1.2-1)

ccl4data: Closed chamber study of CCl4 metabolism by rats.

Description

The results of a closed chamber experiment to determine metabolic parameters for CCl4 (carbon tetrachloride) in rats.

Usage

data(ccl4data)

format

This data frame contains the following columns: \itemtime. The time (in hours after starting the experiment) \iteminitconc. initial chamber concentration (ppm) \itemanimal. This is a repeated measures design; this variable indicates which animal the observation pertains to \itemChamberConc. chamber concentration at time, in ppm

source

Evans, et al. 1994 Applications of sensitivity analysis to a physiologically based pharmacokinetic model for carbon tetrachloride in rats. Toxicology and Applied Pharmacology 128: 36 -- 44.

Examples

plot(ChamberConc ~ time,data=ccl4data,xlab="Time (hours)",
         xlim=range(c(0,ccl4data$time)),
         ylab="Chamber Concentration (ppm)",log="y")
ccl4data.avg<-aggregate(ccl4data$ChamberConc,
                        by=ccl4data[c("time","initconc")],mean)
points(x ~ time,data=ccl4data.avg,pch=16)