RnBeads (version 1.4.0)

combineTestPvalsMeth: combineTestPvalsMeth

Description

combine p-values of multiple tests using (a generalization of) Fisher's method. The parameter setting here is taylored to DNA methylation, but can be adapted. Reference: Makambi, K. (2003). Weighted inverse chi-square method for correlated significance tests. Journal of Applied Statistics, 30(2), 225-234.

Usage

combineTestPvalsMeth(pvalues, testWeights = NULL, correlated = FALSE, methExpectedTestCorrelation = 0.8)

Arguments

pvalues

p-values to combine

testWeights

weights for the individual tests

correlated

are the individual tests correlated

methExpectedTestCorrelation

expected correlation. Empirically approximated to the default value of 0.8 for DNA-methylation

Value

the combined p-value

Examples

p.vals <- 10^-c(0,1,5)
combineTestPvalsMeth(p.vals)