VariantFiltering (version 1.4.3)

deNovo: De Novo variants analysis

Description

This function has been created in order to search for de novo variants in one individual, discarding the ones shared with his/her parents.

Usage

"deNovo"(param, BPPARAM=bpparam("SerialParam"))

Arguments

param

A VariantFilteringParam object built from a multisample VCF file with at least one affected individual and zero or more unaffected ones, and from a PED file specyfing the family relationships among individuals as well as their gender and phenotype status (affected or unaffected).

BPPARAM

An object of class BiocParallelParam specifiying parameters related to the parallel execution of some of the tasks and calculations within this function. See function bpparam() from the BiocParallel package.

Value

An object of class VariantFilteringResults including functional annotations on all selected variants.

Details

This function requires as an input a VariantFilteringParam class object built from an input multisample VCF file, along with a PED file.

References

Elurbe D.M., Mila, M., Castelo, R. The VariantFiltering package, in preparation.

See Also

autosomalRecessiveHomozygous autosomalDominant autosomalRecessiveHeterozygous xLinked VariantFilteringResults

Examples

## Not run: 
# 
# CEUvcf <- file.path(system.file("extdata", package="VariantFiltering"), "CEUtrio.vcf.bgz")
# CEUped <- file.path(system.file("extdata", package="VariantFiltering"), "CEUtrio.ped")
# param <- VariantFilteringParam(vcfFilenames=CEUvcf,
#                      pedFilename=CEUped)
# deNo <- deNovo(param)
# deNo
# ## End(Not run)