it.sol:
Iterative solution for Empirical Bayesian method.
Description
Iterative solution for Empirical Bayesian method.
Usage
it.sol(sdat, g.hat, d.hat, g.bar, t2, a, b, conv = 1e-04)
Arguments
sdat
Standardized matrix of gene expression data.
g.hat
Estimated additive batch effect.
d.hat
Estimated multiplicative batch effect.
t2
Variance of the rows of g.hat.
a
Value of the function aprior applied to multiplicative batch effect.
b
Value of the function bprior applied to multiplicative batch effect.
conv
Convergence threshold.
Value
Matrix of estimated additive and multiplicative batch effects.
Warning
This function is not called by the user directly.References
W. Johnson E., L. Chen, Rabinovic, and A. Adjusting batch effects in microarray expression data using Empirical Bayes methods. Biostatistics, 8(1):118-127, Jan
ary2007. ISSN 1465-4644. doi: http://dx.doi.org/10.1093/biostatistics/kxj037.