leuk2

In this study there were 21 pairs of subjects, and within each pair one subject received 6-mercaptopurine (6-MP) and one got placebo. The data are right censored.
See also Gehan (1965) who used the data ignoring the pairing so that he could illustrate his famous two-sample (non-paired) rank test.

datasets

Calculates nonparametric pointwise confidence intervals for the survival distribution for right censored data, and for medians [Fay and Brittain <DOI:10.1002/sim.6905>]. Has two-sample tests for dissimilarity (e.g., difference, ratio or odds ratio) in survival at a fixed time, and differences in medians [Fay, Proschan, and Brittain <DOI:10.1111/biom.12231>]. Basically, the package gives exact inference methods for one- and two-sample exact inferences for Kaplan-Meier curves (e.g., generalizing Fisher's exact test to allow for right censoring), which are especially important for latter parts of the survival curve, small sample sizes or heavily censored data. Includes mid-p options.

Michael Fay

bpcp

Beta Product Confidence Procedure for Right Censored Data

leuk2 function

A data frame with 42 observations on the following variables.<dl class="dl-horizontal">
 <dt><code>time</code></dt><dd>time in remission (in weeks)</dd>
 <dt><code>status</code></dt><dd>event status, 1 is relapse, 0 is censored</dd>
 <dt><code>treatment</code></dt><dd>treatment group: either 'placebo' or '6-MP'</dd>
 <dt><code>pair</code></dt><dd>pair id number</dd></dl>

leuk2: Acute Leukemia data from Freireich et al (1963).

Description

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Examples