A vector that is the same size as xt, specifying which model each sample belongs to.

model_switch

A vector for the discrete design variables.

The fixed effects parameter values. Supplied as a vector.

bpop

A between subject variability matrix (OMEGA in NONMEM).

A residual unexplained variability matrix (SIGMA in NONMEM).

sigma

A between occasion variability matrix.

docc

poped.db

Compute the FIM for one individual given specific model(s), parameters, design and methods.

internal

Optimal experimental designs for both population and individual
studies based on nonlinear mixed-effect models. Often this is based on a
computation of the Fisher Information Matrix. This package was developed
for pharmacometric problems, and examples and predefined models are available
for these types of systems. The methods are described in Nyberg et al.
(2012) <doi:10.1016/j.cmpb.2012.05.005>, and Foracchia et al. (2004)
<doi:10.1016/S0169-2607(03)00073-7>.

mf3: The Fisher Information Matrix (FIM) for one individual

Description

Usage

Arguments

Value

See Also