dfpk (version 2.0.0)

nextDose: Next dose determination of a phase I clinical trial.

Description

nextDose is used to determine the next or recommended dose level in a phase I clinical trial using Pharmacokinetics (PK).

Usage

nextDose(model, N, y, AUCs, doses, x, theta, p_0, L, betapriors, D_AUC = NULL, options)

Arguments

model

A character string to specify the working model used in the method.

N

The total number of enrolled patients.

y

The toxicity outcome of each patient.

AUCs

The AUCs values of each patient.

doses

The dose levels of the drug.

x

A vector of dose levels assigned to patients in the trial.

theta

The toxicity (probability) target.

p_0

The skeleton of CRM; defaults to NULL. (must be defined only in the PKCRM model)

L

A threshold set before starting the trial; defaults to NULL. (must be defined only in the PKCRM model)

betapriors

A vector of the regression parameters in the model.

D_AUC

A vector specifying the difference between the AUCs and AUC_pop; defaults to NULL.

options

The Stan model's options.

References

Ursino, M., et al, (2016) Dose-finding methods using pharmacokinetics in small populations (under review).

See Also

nsim

Examples

  ## Not run: 
# model <- pktox 
# N <- 15  
# p_0 = 0 
# L = 0
# doses <- c(12.59972,34.65492,44.69007,60.80685,83.68946,100.37111)
# theta <- 0.2 
# options <- list(nchains = 4,niter = 4000,nadapt = 0.9)
# AUCs <- c(1.2303254, 3.3839503,4.3638522, 5.9376084,8.1720269, 9.8009405,
# 1.5330900, 4.2166896, 5.4377306,7.3987646,10.1830398,12.2128046, 2.1126844,
# 5.8108359 ,  7.4934992)
# x <- c(1,1,1,2,2,2,2,2,3,3,3,3,2,3,4)
# y <- c(FALSE, FALSE, FALSE, FALSE, FALSE, FALSE,
# FALSE, FALSE, FALSE, FALSE ,FALSE, TRUE,FALSE, FALSE, FALSE)
# D_AUC <- NULL
# betapriors = NULL
# nextDose(model, N, y, AUCs, doses, x, theta, p_0, L, betapriors, D_AUC, options)
# ## End(Not run)