genefu (version 2.4.2)

npi: Function to compute the Nottingham Prognostic Index

Description

This function computes the Nottingham Prognostic Index (NPI) as published in Galeat et al, 1992. NPI is a clinical index shown to be highly prognostic in breast cancer.

Usage

npi(size, grade, node, na.rm = FALSE)

Arguments

size

tumor size in cm.

grade

Histological grade, i.e. low (1), intermediate (2) and high (3) grade.

node

Nodal status. If only binary nodal status (0/1) is available, map 0 to 1 and 1 to 3.

na.rm

TRUE if missing values should be removed, FALSE otherwise.

Value

• score
  Continuous signature scores
• risk
  Binary risk classification, 1 being high risk and 0 being low risk.

Details

The risk prediction is either Good if score < 3.4, Intermediate if 3.4 <= score="" <-="" 5.4,="" or="" Poor if score > 5.4.

References

Galea MH, Blamey RW, Elston CE, and Ellis IO (1992) "The nottingham prognostic index in primary breast cancer", Breast Cancer Reasearch and Treatment, 22(3):207--219.

See Also

st.gallen

Examples

## load NKI dataset
data(nkis)
## compute NPI score and risk classification
npi(size=demo.nkis[ ,"size"], grade=demo.nkis[ ,"grade"],
  node=ifelse(demo.nkis[ ,"node"] == 0, 1, 3), na.rm=TRUE)