parSeqSim: Parallellized Protein Sequence Similarity Calculation based on Sequence Alignment

Description

Parallellized Protein Sequence Similarity Calculation based on Sequence Alignment

Usage

parSeqSim(protlist, cores = 2, type = "local", submat = "BLOSUM62")

Arguments

protlist

A length n list containing n protein sequences, each component of the list is a character string, storing one protein sequence. Unknown sequences should be represented as ''.

cores

Integer. The number of CPU cores to use for parallel execution, default is 2. Users could use the detectCores() function in the parallel package to see how many cores they could use.

type

Type of alignment, default is 'local', could be 'global' or 'local', where 'global' represents Needleman-Wunsch global alignment; 'local' represents Smith-Waterman local alignment.

submat

Substitution matrix, default is 'BLOSUM62', could be one of 'BLOSUM45', 'BLOSUM50', 'BLOSUM62', 'BLOSUM80', 'BLOSUM100', 'PAM30', 'PAM40', 'PAM70', 'PAM120', 'PAM250'.

Value

A n x n similarity matrix.

Details

This function implemented the parallellized version for calculating protein sequence similarity based on sequence alignment.

Examples

Run this code


# Be careful when testing this since it involves parallelisation
# and might produce unpredictable results in some environments

require(Biostrings)
require(foreach)
require(doParallel)

s1 = readFASTA(system.file('protseq/P00750.fasta', package = 'protr'))[[1]]
s2 = readFASTA(system.file('protseq/P08218.fasta', package = 'protr'))[[1]]
s3 = readFASTA(system.file('protseq/P10323.fasta', package = 'protr'))[[1]]
s4 = readFASTA(system.file('protseq/P20160.fasta', package = 'protr'))[[1]]
s5 = readFASTA(system.file('protseq/Q9NZP8.fasta', package = 'protr'))[[1]]
plist = list(s1, s2, s3, s4, s5)
psimmat = parSeqSim(plist, cores = 2, type = 'local', submat = 'BLOSUM62')
print(psimmat)

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