pbc2


This data is from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of
the liver conducted between 1974 and 1984. A total of 424 PBC patients,
referred to Mayo Clinic during that ten-year interval met eligibility
criteria for the randomized placebo controlled trial of the drug
D-penicillamine, but only the first 312 cases in the data set participated in
the randomized trial. Therefore, the data here are for the 312 patients with
largely complete data.


data

Fits the joint model proposed by Henderson and colleagues (2000)
<doi:10.1093/biostatistics/1.4.465>, but extended to the case of multiple
continuous longitudinal measures. The time-to-event data is modelled using a
Cox proportional hazards regression model with time-varying covariates. The
multiple longitudinal outcomes are modelled using a multivariate version of the
Laird and Ware linear mixed model. The association is captured by a multivariate
latent Gaussian process. The model is estimated using a Monte Carlo Expectation
Maximization algorithm. This project is funded by the Medical Research Council
(Grant number MR/M013227/1).

Graeme L. Hickey

joineRML

Joint Modelling of Multivariate Longitudinal Data and
Time-to-Event Outcomes

pbc2 function

A data frame with 1945 observations on the following 20 variables:
  <dl> </dl>

Format

<code><a rd-options="JM" href="/link/pbc2?package=joineRML&version=0.1.1&to=JM" data-mini-rdoc="JM::pbc2">pbc2</a></code> and <code><a rd-options="survival" href="/link/pbc?package=joineRML&version=0.1.1&to=survival" data-mini-rdoc="survival::pbc">pbc</a></code>.

Source

<code><a rd-options='JM' href='pbc2'>pbc2</a></code> and <code><a rd-options='survival' href='pbc'>pbc</a></code>.

pbc2: Mayo Clinic primary biliary cirrhosis data

Description

Usage

Arguments

Format

Source

References

See Also