The model function for the quadratic model is defined as
$$f(d,\theta)=E_0+\beta_1d+\beta_2d^2$$
Usage
quadratic(dose, e0, b1, b2)
Arguments
dose
Dose variable
e0
Placebo effect
b1
beta1 parameter
b2
beta2 parameter (controls, whether model is convex or concave)
Value
Response value
Details
This model is intended to capture a possible non-monotonic
dose-response relationship.
References
Pinheiro, J. C., Bretz, F. and Branson, M. (2006). Analysis of dose-response studies - modeling
approaches, in N. Ting (ed.). Dose Finding in Drug Development, Springer, New York,
pp. 146--171