Description
Objects of the class Gsri
contain the results of the GSRI analysis.
Objects from the class
Objects of class Gsri
are returned by the gsri
methods.Slots
result
:- Data frame containing the results of the GSRI
estimation, with one row for each gene set and the columns:
pRegGenes
:- Fraction of regulated genes in the gene set
pRegGenesSd
:- Standard deviation of
pRegGenes
obtained
from bootstrapping. nRegGenes
:- Total number of regulated genes in the gene
set.
GSRI('alpha'%)
:- Gene Set Regulation Index, corresponding to
the alpha% quantile of the bootstrapped distribution.
nGenes
:- Total number of genes in the gene set.
cdf
:- List of data frames containing the ECDF of the
p-values. Each data frame covers one gene set, with the columns:
pval
:- P-values obtained from the
test
function. cdf
:- Empirical cumulative density.
parms
:- List containing the parameter values used in
the analysis, with the elements:
weight
:- Weights for each gene in the gene set
nBoot
:- Number of bootstraps for the calculation of the GSRI
test
:- Statistical test function
alpha
:- Confidence level for the GSRI
grenander
:- Application of the Grenander estimatior in the
calculation of the ECDF
testArgs
:- Optional arguments for
test
function
Methods
Analysis:
- gsri:
-
signature(exprs="matrix", groups="factor",
geneSet="missing")
signature(exprs="ExpressionSet", groups="factor",
geneSet="missing")
signature(exprs="matrix", groups="factor",
geneSet="GeneSet")
signature(exprs="ExpressionSet", groups="factor",
geneSet="GeneSet")
signature(exprs="matrix", groups="factor",
geneSet="GeneSetCollection")
signature(exprs="ExpressionSet", groups="factor",
geneSet="GeneSetCollection")
Assess the degree of differential effect in the expression data.
Visualization:
- plot:
-
signature(x="Gsri", y=ANY)
Plot the empirical density of p-values and the corresponding estimated effect. Export to file:
- export:
-
signature(object="Gsri", file="character")
Get methods:
- getGsri:
-
signature(object="Gsri")
- getCdf:
-
signature(object="Gsri")
- getParms:
-
signature(object="Gsri")
Show:
- show:
-
signature(obejct="Gsri")
- summary:
-
signature(obejct="Gsri")