kinsim_single

The function to generate one group of univariate kin pair (e.g., only DZ twins) data using a multivariate norm approach, given the ACE components.

A few functions aim to provide a statistic tool for three purposes. First, simulate kin pairs data based on the assumption that every trait is affected by genetic effects (A), common environmental effects (C) and unique environmental effects (E).Second, use kin pairs data to fit an ACE model and get model fit output.Third, calculate power of A estimate given a specific condition. For the mechanisms of power calculation, we suggest to check Visscher(2004)<doi:10.1375/twin.7.5.505>.

Xuanyu Lyu

ACEsimFit

ACE Kin Pair Data Simulations and Model Fitting

S.Mason Garrison

kinsim_single function

<dl><dt>name</dt>
<dd>Assigned name for the simulated group of kin pairs</dd>
<dt>Rel</dt>
<dd>Genetic relatedness of the simulated kin pairs</dd>
<dt>r_c</dt>
<dd>Assumed common enviroment correlation</dd>
<dt>n</dt>
<dd>The number of generated kin pairs.(n PAIRS of data; The total number of participants is 2n)</dd>
<dt>mu</dt>
<dd>The mean for generated variable</dd>
<dt>ace</dt>
<dd>Vector of variance components under an ACE (additive genetics, common environment, unique environment) structure</dd></dl>

Arguments

kinsim_single — kinsim_single

<dl>

<dt>name</dt>
<dd>Assigned name for the simulated group of kin pairs</dd>


<dt>Rel</dt>
<dd>Genetic relatedness of the simulated kin pairs</dd>


<dt>r_c</dt>
<dd>Assumed common enviroment correlation</dd>


<dt>n</dt>
<dd>The number of generated kin pairs.(n PAIRS of data; The total number of participants is 2n)</dd>


<dt>mu</dt>
<dd>The mean for generated variable</dd>


<dt>ace</dt>
<dd>Vector of variance components under an ACE (additive genetics, common environment, unique environment) structure</dd>

</dl>

kinsim_single: kinsim_single

Description

Usage

Value

Arguments