ADCT (version 0.1.0)

CopriEndpt.Power: Power Calculation for Two Coprimary Endpoints.

Description

Given the group sequential design information, returns the overall power.

Usage

CopriEndpt.Power(n, tau, mu1, mu2, rho, alpha1, alpha2, alternative)

Arguments

n

sample size for the design.

tau

information time for the interim analysis.

mu1

mean value for coprimary endpoint 1.

mu2

mean value for coprimary endpoint 2.

rho

correlation coefficient between two coprimary endpoints.

alpha1

significant level for the first stage.

alpha2

significant level for the second stage.

alternative

indicates the alternative hypothesis and must be one of "two.sided" or "two.sided".

Value

The evaluated power with attributes and computational error.

References

Chang, M. (2014). Adaptive design theory and implementation using SAS and R. CRC Press.

Examples

# Example in Chang (2014) page  272
CopriEndpt.Power(n=197, tau=0.5, mu1=0.2, mu2=0.2, rho=0.5,
alpha1=0.0025, alpha2=0.024, alternative="one.sided")
 sapply(c(-0.8,-0.5,-0.2,0,0.2,0.5,0.8),CopriEndpt.Power,
n=197, tau=0.5, mu1=0.2, mu2=0.2, alpha1=0.0025, alpha2=0.024, alternative="one.sided")