get_af_mat

simulation function: compute allele frequency information variants with allele counts stored in diagonal matrix `AC` from a population of sample size `n_ind`

Provides statistical tools to analyze heterogeneous effects of rare variants within genes that are associated with multiple traits. The package implements methods for assessing pleiotropic effects and identifying allelic heterogeneity, which can be useful in large-scale genetic studies. Methods include likelihood-based statistical tests to assess these effects. For more details, see Lu et al. (2024) <doi:10.1101/2024.10.01.614806>.

Wenhan Lu

ALLSPICER

ALLelic Spectrum of Pleiotropy Informed Correlated Effects

get_af_mat function

<dl><dt>AC</dt>
<dd>a diagonal matrix of allele count information for all variants</dd>
<dt>n_ind</dt>
<dd>total number of individuals in the population</dd></dl>

Arguments

get_af_mat — get_af_mat

<dl>

<dt>AC</dt>
<dd>a diagonal matrix of allele count information for all variants</dd>


<dt>n_ind</dt>
<dd>total number of individuals in the population</dd>

</dl>

get_af_mat: get_af_mat

Description

Usage

Value

Arguments

Examples