potency

An example dataset containing potency data at different
temperatures..

dataset

Estimate the Šesták–Berggren kinetic model (degradation model) from experimental data. A
A closed-form (analytic) solution to the degradation model is implemented as a non-linear fit,
allowing for the extrapolation of the degradation of a drug product - both in time and
temperature. Parametric bootstrap, with kinetic parameters drawn from the multivariate
t-distribution, and analytical formulae (the delta method) are available options to calculate
the confidence and prediction intervals.
The results (modelling, extrapolations and statistical intervals) can be visualised
with multiple plots. The examples illustrate the accelerated stability modelling in drugs and
vaccines development.

Ben Wells

AccelStab

Accelerated Stability Kinetic Modelling

Bernard G Franq

Alex Ball

Daniel Williams

potency function

An object of class <code>"data.frame"</code> with 78 rows and 3 variables<dl>
<dt>Time</dt>
<dd>Time for which the datapoints are gathered.</dd><dt>Potency</dt>
<dd>Measured potency at a time.</dd><dt>Celsius</dt>
<dd>The temperature in celsius.</dd></dl>

Format

Potency Accelerated Stability Data — potency

An object of class <code>"data.frame"</code> with 78 rows and 3 variables<dl>
<dt>Time</dt>
<dd>Time for which the datapoints are gathered.</dd>

<dt>Potency</dt>
<dd>Measured potency at a time.</dd>

<dt>Celsius</dt>
<dd>The temperature in celsius.</dd>



</dl>

potency: Potency Accelerated Stability Data

Description

Usage

Arguments

Format