GenCovar

Generate an (n x 6) covariate matrix with columns representing an intercept,
age, sex, and 3 genetic PCs. Because these simulations address rare variant
analysis, correlation between genotypes and the genetic PCs (based on
common variants) is unnecessary.

Implementation of gene-level rare variant association tests targeting allelic series: genes where increasingly deleterious mutations have increasingly large phenotypic effects. The COding-variant Allelic Series Test (COAST) operates on the benign missense variants (BMVs), deleterious missense variants (DMVs), and protein truncating variants (PTVs) within a gene. COAST uses a set of adjustable weights that tailor the test towards rejecting the null hypothesis for genes where the average magnitude of effect increases monotonically from BMVs to DMVs to PTVs. See McCaw ZR, O’Dushlaine C, Somineni H, Bereket M, Klein C, Karaletsos T, Casale FP, Koller D, Soare TW. (2022) "An allelic series rare variant association test for candidate gene discovery" <doi:10.1101/2022.12.23.521658>.

Zachary McCaw

AllelicSeries

Allelic Series Test

Christoph Klein

insitro 

GenCovar function

<dl><dt>n</dt>
<dd>Sample size.</dd></dl>

Arguments

Generate Covariates — GenCovar

<dl>

<dt>n</dt>
<dd>Sample size.</dd>

</dl>

GenCovar: Generate Covariates

Description

Usage

Value

Arguments