get.pgs.percentiles

Calculate percentiles and report decile and quartile ranks for a vector of polygenic scores

Simple and transparent parsing of genotype/dosage data
from an input Variant Call Format (VCF) file, matching of genotype
coordinates to the component Single Nucleotide Polymorphisms (SNPs)
of an existing polygenic score (PGS), and application of SNP weights
to dosages for the calculation of a polygenic score for each individual
in accordance with the additive weighted sum of dosages model. Methods
are designed in reference to best practices described by
Collister, Liu, and Clifton (2022) <doi:10.3389/fgene.2022.818574>.

Paul Boutros

ApplyPolygenicScore

Utilities for the Application of a Polygenic Score to a VCF

Nicole Zeltser

Rachel Dang

Raag Agrawal

get.pgs.percentiles function

<dl><dt>pgs</dt>
<dd>numeric vector of polygenic scores</dd>
<dt>n.percentiles</dt>
<dd>integer number of percentiles to calculate (optional)</dd></dl>

Arguments

get.pgs.percentiles — get.pgs.percentiles

<dl>

<dt>pgs</dt>
<dd>numeric vector of polygenic scores</dd>


<dt>n.percentiles</dt>
<dd>integer number of percentiles to calculate (optional)</dd>

</dl>

get.pgs.percentiles: get.pgs.percentiles

Description

Usage

Value

Arguments

Examples