be2x2

It performs conventional bioequivalence test for 2x2 study. Input is a file. Basic assumption is that the variable is distributed as a log-normal distribution. This is SAS PROC GLM style. If you want PROC MIXED style, use <code><a href="/link/nlme%3A%3Alme?package=BE&version=0.2.4" data-mini-rdoc="BE::nlme::lme">nlme::lme</a></code>.

report

Analyze bioequivalence study data with industrial strength. Sample size could be determined for various crossover designs, such as 2x2 design, 2x4 design, 4x4 design, Balaam design, Two-sequence dual design, and William design.
Reference: Chow SC, Liu JP. Design and Analysis of Bioavailability and Bioequivalence Studies. 3rd ed. (2009, ISBN:978-1-58488-668-6).

Kyun-Seop Bae

Bioequivalence Study Data Analysis

be2x2 function

<dl> <dt>Data</dt>
<dd>A <code>data.frame</code> or a csv file name. This should have at least the following columns and variable column(s) to be tested. AUC and Cmax should be all positive values.<pre><code> 
 GRP : Group or Sequence, 'RT' or 'TR'
 PRD : Period, 1 or 2
 SUBJ : Subject ID
 TRT : Treatment or Drug, 'R' or 'T'
</code></pre></dd> <dt>Columns</dt>
<dd>Column names of variables to be tested. This is usaully c("AUClast", "Cmax", "Tmax") or c("AUClast", "AUCinf", "Cmax", "Tmax")</dd> <dt>rtfName</dt>
<dd>Output filename of rich text format(rtf)</dd></dl>

Arguments

Author

It performs conventional bioequivalence test for 2x2 study. Input is a file. Basic assumption is that the variable is distributed as a log-normal distribution. This is SAS PROC GLM style. If you want PROC MIXED style, use <code><a href='https://rdrr.io/pkg/nlme/man/lme.html'>nlme::lme</a></code>.

Bioequivalence test of a 2x2 study — be2x2

<dl>

 <dt>Data</dt>
<dd>A <code>data.frame</code> or a csv file name. This should have at least the following columns and variable column(s) to be tested. AUC and Cmax should be all positive values.<pre><code> 
 GRP : Group or Sequence, 'RT' or 'TR'
 PRD : Period, 1 or 2
 SUBJ : Subject ID
 TRT : Treatment or Drug, 'R' or 'T'
</code></pre></dd>

 <dt>Columns</dt>
<dd>Column names of variables to be tested. This is usaully c("AUClast", "Cmax", "Tmax") or c("AUClast", "AUCinf", "Cmax", "Tmax")</dd>

 <dt>rtfName</dt>
<dd>Output filename of rich text format(rtf)</dd>

</dl>

be2x2: Bioequivalence test of a 2x2 study

Description

Usage

Value

Arguments

Author

Details

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Examples