isobologram

Output of <code><a rd-options="" href="/link/fitSurface?package=BIGL&version=1.5.3" data-mini-rdoc="BIGL::fitSurface">fitSurface</a></code>

Number of concentrations to plot for each compound in the
contour plot. An evenly spaced grid of doses will be generated for each
compound given its respective observed minimum and maximum doses. Note that
<code>grid.len^2</code> computations will be needed later so this number should
stay reasonably low.

grid.len

If <code>logScale = TRUE</code>, then grid of doses is evenly
spaced in the logarithmic scale.

logScale

Further parameters that are not used at this moment.

If transformation functions are used, then the isobologram response levels
will be plotted on the transformed scale.

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Maxim Nazarov

BIGL

Biochemically Intuitive Generalized Loewe Model

isobologram function

Output of <code><a rd-options='' href='fitSurface'>fitSurface</a></code>

isobologram: Isobologram of the response surface predicted by the null model

Description

Usage

Arguments