GetStartGuess

Estimate initial values for dose-response curve fit

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Maxim Nazarov

BIGL

Biochemically Intuitive Generalized Loewe Model

GetStartGuess function

<dl><dt>df</dt>
<dd>Dose-response dataframe containing <code>"dose"</code> and
<code>"effect"</code> columns</dd>
<dt>transforms</dt>
<dd>Transformation functions. If non-null, <code>transforms</code> is
a list containing 5 elements, namely biological and power transformations
along with their inverse functions and <code>compositeArgs</code> which is a list
with argument values shared across the 4 functions. See vignette for more
information.</dd></dl>

Arguments

Estimate initial values for dose-response curve fit — GetStartGuess

<dl>

<dt>df</dt>
<dd>Dose-response dataframe containing <code>"dose"</code> and
<code>"effect"</code> columns</dd>


<dt>transforms</dt>
<dd>Transformation functions. If non-null, <code>transforms</code> is
a list containing 5 elements, namely biological and power transformations
along with their inverse functions and <code>compositeArgs</code> which is a list
with argument values shared across the 4 functions. See vignette for more
information.</dd>

</dl>

GetStartGuess: Estimate initial values for dose-response curve fit

Description

Usage

Arguments