4-parameter logistic dose-response function

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Kathy Mutambanengwe

BIGL

Biochemically Intuitive Generalized Loewe Model

Heather Turner

Annelies Tourny

Olivier Thas

Maxim Nazarov

Rytis Bagdziunas

Stijn Hawinkel

L4 function

<dl><dt>dose</dt>
<dd>Dose level</dd>
<dt>b</dt>
<dd>Hill's coefficient (slope of the curve)</dd>
<dt>L</dt>
<dd>Baseline effect (at zero dose)</dd>
<dt>U</dt>
<dd>Asymptote effect (at infinite dose)</dd>
<dt>logEC50</dt>
<dd>Point of inflection (in logarithmic terms)</dd></dl>

Arguments

4-parameter logistic dose-response function — L4

<dl>

<dt>dose</dt>
<dd>Dose level</dd>


<dt>b</dt>
<dd>Hill's coefficient (slope of the curve)</dd>


<dt>L</dt>
<dd>Baseline effect (at zero dose)</dd>


<dt>U</dt>
<dd>Asymptote effect (at infinite dose)</dd>


<dt>logEC50</dt>
<dd>Point of inflection (in logarithmic terms)</dd>

</dl>

L4: 4-parameter logistic dose-response function

Description

Usage

Arguments