directAntivirals

A dataset containing 11 combination experiments of direct-acting antivirals.

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Kathy Mutambanengwe

BIGL

Biochemically Intuitive Generalized Loewe Model

Heather Turner

Annelies Tourny

Olivier Thas

Maxim Nazarov

Rytis Bagdziunas

Stijn Hawinkel

directAntivirals function

A data frame with 3520 rows and 6 variables:<ul>
<li>experiment: ID of experiment (1-11)</li>
<li>cpd1: name of the first compound (4 different compounds)</li>
<li>cpd2: name of the second compound (11 different compounds)</li>
<li>effect: observed effect (cell count)</li>
<li>d1: dose of the first compound</li>
<li>d2: dose of the second compound</li>
</ul>

Format

Partial data with combination experiments of direct-acting antivirals — directAntivirals

Partial data with combination experiments of direct-acting antivirals

directAntivirals: Partial data with combination experiments of direct-acting antivirals

Description

Arguments

Format