getCP

This function is generally called from within <code>fitSurface</code>.

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Kathy Mutambanengwe

BIGL

Biochemically Intuitive Generalized Loewe Model

Heather Turner

Annelies Tourny

Olivier Thas

Maxim Nazarov

Rytis Bagdziunas

Stijn Hawinkel

getCP function

<dl><dt>bootStraps</dt>
<dd>the bootstraps carried out already</dd>
<dt>null_model</dt>
<dd>Specified null model for the expected response surface.
Currently, allowed options are <code>"loewe"</code> for generalized Loewe model,
<code>"hsa"</code> for Highest Single Agent model, <code>"bliss"</code> for Bliss additivity,
and <code>"loewe2"</code> for the alternative Loewe generalization.</dd>
<dt>transforms</dt>
<dd>Transformation functions. If non-null, <code>transforms</code> is
a list containing 5 elements, namely biological and power transformations
along with their inverse functions and <code>compositeArgs</code> which is a list
with argument values shared across the 4 functions. See vignette for more
information.</dd>
<dt>sigma0</dt>
<dd>standard deviation of the null model on the real data</dd>
<dt>doseGrid</dt>
<dd>a grid of dose combinations</dd></dl>

Arguments

Estimate CP matrix from bootstraps — getCP

<dl>

<dt>bootStraps</dt>
<dd>the bootstraps carried out already</dd>


<dt>null_model</dt>
<dd>Specified null model for the expected response surface.
Currently, allowed options are <code>"loewe"</code> for generalized Loewe model,
<code>"hsa"</code> for Highest Single Agent model, <code>"bliss"</code> for Bliss additivity,
and <code>"loewe2"</code> for the alternative Loewe generalization.</dd>


<dt>transforms</dt>
<dd>Transformation functions. If non-null, <code>transforms</code> is
a list containing 5 elements, namely biological and power transformations
along with their inverse functions and <code>compositeArgs</code> which is a list
with argument values shared across the 4 functions. See vignette for more
information.</dd>


<dt>sigma0</dt>
<dd>standard deviation of the null model on the real data</dd>


<dt>doseGrid</dt>
<dd>a grid of dose combinations</dd>

</dl>

getCP: Estimate CP matrix from bootstraps

Description

Usage

Value

Arguments