getR

Helper functions for the test statistics

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Kathy Mutambanengwe

BIGL

Biochemically Intuitive Generalized Loewe Model

Heather Turner

Annelies Tourny

Olivier Thas

Maxim Nazarov

Rytis Bagdziunas

Stijn Hawinkel

getR function

<dl><dt>data</dt>
<dd>the datasets</dd>
<dt>idUnique</dt>
<dd>id of unique off axis points</dd>
<dt>transforms</dt>
<dd>Transformation functions. If non-null, <code>transforms</code> is
a list containing 5 elements, namely biological and power transformations
along with their inverse functions and <code>compositeArgs</code> which is a list
with argument values shared across the 4 functions. See vignette for more
information.</dd>
<dt>respS</dt>
<dd>the evaluated response surface</dd></dl>

Arguments

Helper functions for the test statistics — getR

<dl>

<dt>data</dt>
<dd>the datasets</dd>


<dt>idUnique</dt>
<dd>id of unique off axis points</dd>


<dt>transforms</dt>
<dd>Transformation functions. If non-null, <code>transforms</code> is
a list containing 5 elements, namely biological and power transformations
along with their inverse functions and <code>compositeArgs</code> which is a list
with argument values shared across the 4 functions. See vignette for more
information.</dd>


<dt>respS</dt>
<dd>the evaluated response surface</dd>

</dl>

getR: Helper functions for the test statistics

Description

Usage

Arguments