harbronLoewe

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Kathy Mutambanengwe

BIGL

Biochemically Intuitive Generalized Loewe Model

Heather Turner

Annelies Tourny

Olivier Thas

Maxim Nazarov

Rytis Bagdziunas

Stijn Hawinkel

harbronLoewe function

<dl><dt>doseInput</dt>
<dd>Dose-response dataframe containing <code>"d1"</code> and
<code>"d2"</code> columns</dd>
<dt>parmInput</dt>
<dd>Numeric vector or list with appropriately named
parameter inputs. Typically, it will be coefficients from a
<code>MarginalFit</code> object.</dd>
<dt>asymptotes</dt>
<dd>Number of asymptotes. It can be either <code>1</code>
as in standard Loewe model or <code>2</code> as in generalized Loewe model.</dd>
<dt>startvalues</dt>
<dd>Starting values for the non-linear equation,
from the observed data</dd>
<dt>newtonRaphson</dt>
<dd>a boolean, is Newton raphson used for finding the
response surface? May be faster but also less stable</dd>
<dt>...</dt>
<dd>Further arguments that are currently unused</dd></dl>

Arguments

Alternative Loewe generalization — harbronLoewe

<dl>

<dt>doseInput</dt>
<dd>Dose-response dataframe containing <code>"d1"</code> and
<code>"d2"</code> columns</dd>


<dt>parmInput</dt>
<dd>Numeric vector or list with appropriately named
parameter inputs. Typically, it will be coefficients from a
<code>MarginalFit</code> object.</dd>


<dt>asymptotes</dt>
<dd>Number of asymptotes. It can be either <code>1</code>
as in standard Loewe model or <code>2</code> as in generalized Loewe model.</dd>


<dt>startvalues</dt>
<dd>Starting values for the non-linear equation,
from the observed data</dd>


<dt>newtonRaphson</dt>
<dd>a boolean, is Newton raphson used for finding the
response surface? May be faster but also less stable</dd>


<dt>...</dt>
<dd>Further arguments that are currently unused</dd>

</dl>

Alternative Loewe generalization

harbronLoewe: Alternative Loewe generalization

Description

Usage

Arguments