predictVar

Response surface methods for drug synergy analysis. Available
methods include generalized and classical Loewe formulations as well as Highest
Single Agent methodology. Response surfaces can be plotted in an interactive
3-D plot and formal statistical tests for presence of synergistic effects are
available. Implemented methods and tests are described in the article
"BIGL: Biochemically Intuitive Generalized Loewe null model for prediction
of the expected combined effect compatible with partial agonism and antagonism"
by Koen Van der Borght, Annelies Tourny, Rytis Bagdziunas, Olivier Thas,
Maxim Nazarov, Heather Turner, Bie Verbist & Hugo Ceulemans (2017)
<doi:10.1038/s41598-017-18068-5>.

Kathy Mutambanengwe

BIGL

Biochemically Intuitive Generalized Loewe Model

Heather Turner

Annelies Tourny

Olivier Thas

Maxim Nazarov

Rytis Bagdziunas

Stijn Hawinkel

predictVar function

<dl><dt>means</dt>
<dd>a vector of means</dd>
<dt>model</dt>
<dd>The mean-variance model</dd>
<dt>invTransFun</dt>
<dd>the inverse transformation function, back to the variance domain</dd></dl>

Arguments

Predict variance — predictVar

<dl>

<dt>means</dt>
<dd>a vector of means</dd>


<dt>model</dt>
<dd>The mean-variance model</dd>


<dt>invTransFun</dt>
<dd>the inverse transformation function, back to the variance domain</dd>

</dl>

Predict variance

predictVar: Predict variance

Description

Usage

Arguments