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BIGr

Core Genomic Analysis Functions for Breeding Insight

BIGr is an R package developed by Breeding Insight that provides a robust set of functions for analyzing genomic and pedigree data in diploid and polyploid breeding programs. It's designed to streamline the analysis of breeding and genetic data, empowering researchers and breeders to make informed decisions.

Installation

To install BIGr, you'll need to have BiocManager installed.

if (!require("BiocManager", quietly = TRUE))
    install.packages("BiocManager")
    install.packages("remotes")

BiocManager::install("Breeding-Insight/BIGr", dependencies = TRUE)
library(BIGr)

Funding

BIGr development is supported by Breeding Insight, a USDA-funded initiative based at Cornell University.

Citation

If you use BIGr in your research, please cite as:

Sandercock, Alexander M., Cristiane H. Taniguti, Josue Chinchilla-Vargas, Dongyan Zhao, Shufen Chen, Meng Lin, Manoj Sapkota, and Breeding Insight Team. 2025. “Breeding Insight Genomics Functions for Polypoid and Diploid Species.” https://github.com/Breeding-Insight/BIGr.

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Version

Install

install.packages('BIGr')

Monthly Downloads

153

Version

0.6.2

License

Apache License (>= 2)

Issues

Pull Requests

Stars

Forks

Maintainer

Alexander M. Sandercock

Last Published

September 18th, 2025

Functions in BIGr (0.6.2)

thinSNP

Thin a dataframe of SNPs based on genomic position
updog2vcf

Export Updog Results as VCF
solve_composition_poly

Compute Genome-Wide Breed Composition
merge_MADCs

Merge MADC files
check_ped

Evaluate Pedigree File for Accuracy
check_replicates

Compatibility Between Samples Genotypes
allele_freq_poly

Compute Allele Frequencies for Populations
dosage2vcf

Convert DArTag Dosage and Counts to VCF
filterMADC

Filter MADC Files
calculate_Het

Calculate Observed Heterozygosity from a Genotype Matrix
dosage_ratios

Calculate the Percentage of Each Dosage Value
filterVCF

Filter a VCF file
check_homozygous_trios

Check Homozygous Loci in Trios
calculate_MAF

Calculate Minor Allele Frequency from a Genotype Matrix
get_countsMADC

Obtain Read Counts from MADC File
flip_dosage

Switch Dosage Values from a Genotype Matrix
madc2vcf_all

Converts MADC file to VCF recovering target and off-target SNPs
imputation_concordance

Calculate Concordance between Imputed and Reference Genotypes
madc2vcf_targets

Format MADC Target Loci Read Counts Into VCF
madc2gmat

Convert MADC Files to an Additive Genomic Relationship Matrix