BayesFBHborrow (version 2.0.2)

GibbsMH.NoBorrow: GibbsMH sampler, without Bayesian Borrowing

Description

An MCMC sampler for time-to-event data, without Bayesian Borrowing. We obtain a flexible baseline hazard function by making the split points random within a piecewise exponential model and using a Gaussian Markov random field prior to smooth the baseline hazards. Only calls the sampler and does not run any input checks. Best practice is to call BayesFBHborrow(), if the user is not familiar with the model at hand.

Usage

# S3 method for NoBorrow
GibbsMH(
  Y,
  I,
  X = NULL,
  Y_0 = NULL,
  I_0 = NULL,
  X_0 = NULL,
  tuning_parameters,
  hyperparameters = list(a_sigma = 1, b_sigma = 1, phi = 3, clam_smooth = 0.8),
  lambda_hyperparameters = list(a_lambda = 0.01, b_lambda = 0.01),
  iter = 1500L,
  warmup_iter = 10L,
  refresh = 0,
  max_grid = 2000L
)

Value

list with values after each iteration for parameters: out_fixed (J, mu, sigma2, beta), lambda, s, as well as tuning values of the total number of accepts: lambda_move and beta_move. Also included is the out_slam which contains the shrunk estimate of the baseline hazard.

Arguments

Y

data

I

event indicator

X

design matrix

Y_0

historical data, default is NULL

I_0

historical event indicator, default is NULL

X_0

historical design matrix, default is NULL

tuning_parameters

list of "cprop_beta", "Jmax", and "pi_b"

hyperparameters

list containing the hyperparameters c("a_sigma", "b_sigma", "Jmax", "clam_smooth", "cprop_beta", "phi"). Default is list("a_sigma" = 2, "b_sigma" = 2, "Jmax" = 20, "clam_smooth" = 0.8, "cprop_beta" = 0.5, "phi" = 3)

lambda_hyperparameters

contains two hyperparameters ("a" and "b") used for the update of lambda, default is c(0.01, 0.01)

iter

number of iterations for MCMC sampler, excluding warmup, default is 2000

warmup_iter

number of warmup iterations (burn-in) for MCMC sampler, default is 2000

refresh

number of iterations between printed screen updates, default is 500

max_grid

grid size for the smoothed baseline hazard, default is 2000

Examples

set.seed(123)
# Load example data and set your hyper parameters
data(weibull_cc, package = "BayesFBHborrow")
data(weibull_hist, package = "BayesFBHborrow")

# The datasets consists of 3 (2) columns named "tte", "event" and "X".
# To explicitly run the sampler, extract the samples as following
Y <- weibull_cc$tte
I <- weibull_cc$event
X <- matrix(weibull_cc$X_trt)

# Specify hyperparameters and tuning parameters
hyper <-  list("a_sigma" = 2,
               "b_sigma" = 2,
               "clam_smooth" = 0.5,
               "phi" = 3)

tuning_parameters <- list("Jmax" = 5,
                          "pi_b" = 0.5,
                          "cprop_beta" = 0.5)
                          
# Set initial values to 'NULL' for default settings
output <- GibbsMH(Y, I, X, NULL, NULL, NULL,
                  tuning_parameters = tuning_parameters, hyperparameters = hyper, 
                  iter = 5, warmup_iter = 1)