BiSEp (version 1.0)

FURE: FURE: Functional redundancy between synthetic lethal gene pairs

Description

Utilises gene ontology information from the GO database bioconductor package. Assesses gene pairs output from the SLinG and BEEM tools for gene ontology functional redundancy. Performs semantic similarity scoring utilising the GOSemSim bioconductor package

Usage

FURE(
	x7 = data, 
	inputType = inputType)

Arguments

x7

This should be the output matrix (or similar) from the SLinG and BEEM tools. Columns 1 and 2 should be gene symbols.

inputType

Either 'S' for SLING or 'B' for BEEM based on origin of the input matrix.

Value

• A list of matrices containing gene pairs with associated synthetic lethal statistical significance values + gene ontology annotation/ scores.

Examples

data(FURE_example_input)
outputFURE <- FURE(x7=FURE_example_input, inputType='S')