BiSEp (version 2.3)

Toolkit to Identify Candidate Synthetic Lethality

Description

Enables the user to infer potential synthetic lethal relationships by analysing relationships between bimodally distributed gene pairs in big gene expression datasets. Enables the user to visualise these candidate synthetic lethal relationships.

Copy Link

Version

Install

install.packages('BiSEp')

Monthly Downloads

296

Version

2.3

License

Artistic-2.0

Maintainer

Mark Wappett

Last Published

May 4th, 2024

Functions in BiSEp (2.3)

BIGEE

BIGEE: Bimodal Gene Expression Exclusivity.

BISEP_dat

A list object containing 3 data frames.

MUT_data

A matrix containing discreet mutation calls

FURE_data

Output matrix from the BIGEE tool

BISEP_data

A list object containing 3 data frames.

INPUT_data

A Log2 Gene Expression matrix

expressionPlot

expressionPlot: Create visualisations from BIGEE output

waterfallPlot

waterfallPlot: Create visualisations from BEEM output

BEEM

BEEM: Bimodal Expression Exclusive with Mutation

BiSEp-package

BiSEp: Bimodality in gene expression to dissect tumours and reveal synthetic lethal drug targets and biomarkers

FURE

FURE: Functional redundancy between synthetic lethal gene pairs

BISEP

BISEP: Bimodality in Gene Expression data.