Routines for the functional analysis of biological networks
Description
This package provides functions for the integrated
analysis of protein-protein interaction networks and the
detection of functional modules. Different datasets can be
integrated into the network by assigning p-values of
statistical tests to the nodes of the network. E.g. p-values
obtained from the differential expression of the genes from an
Affymetrix array are assigned to the nodes of the network. By
fitting a beta-uniform mixture model and calculating scores
from the p-values, overall scores of network regions can be
calculated and an integer linear programming algorithm
identifies the maximum scoring subnetwork.