Data from the Profil trial, a multiple crossover study where 38 patients had repeat blocks. Each block lasted 3 weeks and corresponded to a sequence of all three treatments (placebo, sildenafil 40mg, or sildenafil 80mg), each treatment being allocated during 1 week. The principal outcome were Raynaud Condition Score (RCS) and the frequency and cumulative duration of attacks over 24 hours.
id: study participant.
age: age in years, between 18 and 74 years.
male: indicator of whether the participant was a male.
period: number of the block for a given patient. From 1 to 5.
time: number of days since inclusion.
treatment: treatment allocated during the period (placebo, lowDose, highDose)
rcs: RCS score, ranging from 0 to 10.
number: daily number of attack, ranging from 0 to 9.
duration: cumulative daily duration of attacks in minutes, between 0 and 755 minutes.
data(profil, package = "BuyseTest")An object of class data.frame with 2306 rows and 9 columns.
Brice Ozenne took a subset of the columns from the original dataset (available at https://datadryad.org/dataset/doi:10.5061/dryad.c670tq2) and translated their names into english.
Matthieu Roustit, Joris Giai, Olivier Gaget, et al. On-Demand Sildenafil as a Treatment for Raynaud Phenomenon: A Series of n-of-1 Trials. Ann Intern Med.2018;169:694-703. [Epub 30 October 2018]. doi:10.7326/M18-0517