calculateGenePval

Code was adapted from R package gscreend. The alpha-RRA method is 
adapted from MAGeCK.

Provides analytical methods for analyzing CRISPR screen data
at different levels of gene expression. Multi-component normal mixture models
and EM algorithms are used for modeling.

Lianbo Yu

CEDA

CRISPR Screen and Gene Expression Differential Analysis

Yue Zhao

Lang Li

calculateGenePval function

<dl><dt>pvec</dt>
<dd>A numeric vector containing p-values of sgRNAs.</dd>
<dt>genes</dt>
<dd>A character string containing gene names corresponding 
to sgRNAs.</dd>
<dt>alpha</dt>
<dd>A numeric number denoting the alpha cutoff (i.e. 0.05).</dd>
<dt>nperm</dt>
<dd>Number of permutations, default is 20</dd></dl>

Arguments

Calculating gene level p-values using modified robust rank aggregation
(alpha-RRA method) on sgRNAs' p-values — calculateGenePval

<dl>

<dt>pvec</dt>
<dd>A numeric vector containing p-values of sgRNAs.</dd>


<dt>genes</dt>
<dd>A character string containing gene names corresponding 
to sgRNAs.</dd>


<dt>alpha</dt>
<dd>A numeric number denoting the alpha cutoff (i.e. 0.05).</dd>


<dt>nperm</dt>
<dd>Number of permutations, default is 20</dd>

</dl>

calculateGenePval: Calculating gene level p-values using modified robust rank aggregation (alpha-RRA method) on sgRNAs' p-values

Description

Usage

Value

Arguments