CHAP-GWAS: Leveraging Chromosomal Haplotypes to Improve
Genome-Wide Association Studies
Description
CHAP-GWAS (Chromosomal Haplotype-Integrated Genome-Wide Association
Study) provides a dynamically adaptive framework for genome-wide association
studies (GWAS) that integrates chromosome-scale haplotypes with single
nucleotide polymorphism (SNP) analysis. The method identifies and extends
haplotype variants based on their phenotypic associations rather than
predefined linkage blocks, enabling high-resolution detection of quantitative
trait loci (QTL). By leveraging long-range phased haplotype information,
CHAP-GWAS improves statistical power and offers a more comprehensive view of
the genetic architecture underlying complex traits.