TestRatioThreshold


numeric. The considered maximum order of epistatic interactions. It must be setted as 1, 2, 3, 4, or 5.


MaxOrder


character. It controls the numbers of detected SNPs or SNP-combinations with the help of NumberThreshold. The length of RatioThreshold is equal to MaxOrder. Each element is a decimal in [0,1] with the character format.


RatioThreshold


This function check the parameter RatioThreshold.


Detecting and visualizing nonlinear interaction effects of single nucleotide polymorphisms or epistatic interactions, especially high-order epistatic interactions, are important topics in bioinformatics because of their significant mathematical and computational challenges. We present CINOEDV (Co-Information based N-Order Epistasis Detector and Visualizer) for detecting, visualizing, and analyzing high-order epistatic interactions by introducing virtual vertices into the construction of a hypergraph. CINOEDV was developed as an alternative to existing software to build a global picture of epistatic interactions and unexpected high-order epistatic interactions, which might provide useful clues for understanding the underlying genetic architecture of complex diseases.

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TestRatioThreshold: Test the parameter RatioThreshold

Description

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Examples