COMPASS-package


This package implements a model for the analysis of polyfunctionality
in single-cell cytometry experiments. The model effectively
identifies combinations of markers that are differentially expressed
between samples of cells subjected to different stimulations.


COMPASS is a statistical framework that enables unbiased analysis
of antigen-specific T-cell subsets. COMPASS uses a Bayesian hierarchical
framework to model all observed cell-subsets and select the most likely
to be antigen-specific while regularizing the small cell counts that often
arise in multi-parameter space. The model provides a posterior probability
of specificity for each cell subset and each sample, which can be used to
profile a subject's immune response to external stimuli such as infection
or vaccination.

Greg Finak

COMPASS

Combinatorial Polyfunctionality Analysis of Single Cells

COMPASS-package function

This package implements a model for the analysis of polyfunctionality
in single-cell cytometry experiments. The model effectively
identifies combinations of markers that are differentially expressed
between samples of cells subjected to different stimulations.

COMPASS-package: COMPASS (Combinatorial Polyfunctionality Analysis of Single-Cells)

Description

Arguments

See Also