FunctionalityScore

FunctionalityScore.COMPASSResult

FunctionalityScore.default

An object of class <code>COMPASSResult</code>, as returned by
<code><a rd-options="" href="/link/COMPASS?package=COMPASS&version=1.10.2" data-mini-rdoc="COMPASS::COMPASS">COMPASS</a></code>. Alternatively, a matrix of functionality scores,
used under the assumption that the 'null' category has been dropped.

The number of markers included in an experiment. It is inferred
from the data when <code>x</code> is a <code>COMPASSResult</code>.


Computes the functionality score for each observation from the gamma matrix
of a COMPASS model fit. The scores are normalized according to the total
number of possible subsets that could be observed (<code>2^M - 1</code>).


COMPASS is a statistical framework that enables unbiased analysis
of antigen-specific T-cell subsets. COMPASS uses a Bayesian hierarchical
framework to model all observed cell-subsets and select the most likely
to be antigen-specific while regularizing the small cell counts that often
arise in multi-parameter space. The model provides a posterior probability
of specificity for each cell subset and each sample, which can be used to
profile a subject's immune response to external stimuli such as infection
or vaccination.

Greg Finak

COMPASS

Combinatorial Polyfunctionality Analysis of Single Cells

FunctionalityScore function

An object of class <code>COMPASSResult</code>, as returned by
<code><a href="COMPASS" rd-options="">COMPASS</a></code>. Alternatively, a matrix of functionality scores,
used under the assumption that the 'null' category has been dropped.

Computes the functionality score for each observation from the gamma matrix
of a COMPASS model fit. The scores are normalized according to the total
number of possible subsets that could be observed (<code>2^M - 1</code>).

FunctionalityScore: Compute the Functionality Score for each subject fit in a COMPASS model

Description

Usage

Arguments

Value

Examples