COSINE (version 1.0)

diff_gen_PPI: Generate the scaled node score and scaled edge score for nodes and edges in the background network

Description

Compute the F-statistic and ECF-statistic and then standardize them

Usage

diff_gen_PPI(data1, data2, PPI)

Arguments

data1

The first gene expression dataset(with rows corresponding to samples)

data2

The second gene expression dataset

PPI

A matrix with two columns containing the protein interaction pairs

Value

• A list containing:
• scaled_node_score
  The standardized F-statistic measuring the differential expression of each gene
• scaled_edge_score
  The standardized ECF-statistic measuring the differential correlation of each gene pair

Examples

data(simulated_data)
data(PPI)
data1 <- simulated_data[[1]]
data2 <- simulated_data[[7]]
colnames(data1)<-colnames(data2)<-as.character(1:500)
test <- diff_gen_PPI(data1[,1:20],data2[,1:20],PPI)