featureVectors
a data frame generated from buildFeatureVectorForScoring. It contains
IsMismatch.posX (Indicator variable indicating whether this position X is
mismatch or not, 1 means yes and 0 means not, X = 1- gRNA.size) representing
all positions in the gRNA), strand (strand of the off target, + for plus
and - for minus strand), chrom (chromosome of the off target), chromStart
(start position of the off target), chromEnd (end position of the off target),
name (gRNA name),gRNAPlusPAM (gRNA sequence with PAM sequence
concatenated), OffTargetSequence (the genomic sequence of the off target),
n.mismatch (number of mismatches between the off target and the gRNA),
forViewInUCSC (string for viewing in UCSC genome browser, e.g.,
chr14:31665685-31665707), score (score of the off target),
mismatch.distance2PAM (a comma separated distances of all mismatches to
PAM, e.g., 14,11 means one mismatch is 14 bp away from PAM and the other
mismatch is 11 bp away from PAM), alignment (alignment between gRNA and off
target, e.g., ......G..C.......... means that this off target aligns with
gRNA except that G and C are mismatches),NGG (this off target contains
canonical PAM or not, 1 for yes and 0 for no) mean.neighbor.distance.mismatch
(mean distance between neighboring mismatches)
weights
a numeric vector size of gRNA length, default c(0, 0, 0.014, 0, 0, 0.395,
0.317, 0, 0.389, 0.079, 0.445, 0.508, 0.613, 0.851, 0.732, 0.828, 0.615, 0.804,
0.685, 0.583) which is used in Hsu et al., 2013 cited in the reference section