NlmeCovariateParameter-class

NlmeCovariateParameter

Class represents an NLME Covariate parameter

internal

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
modeling. The package provides access to the same advanced Maximum Likelihood
algorithms used by the NLME-Engine in the Phoenix platform. These tools support
a range of analyses, from parametric methods to individual and pooled data, and
support integrated use within the Pirana pharmacometric workbench
<doi:10.1002/psp4.70067>. Execution is supported both locally or on
remote machines.

James Craig

Certara.RsNLME

Pharmacometric Modeling

Michael Tomashevskiy

Vitalii Nazarov

Shuhua Hu

Soltanshahi Fred

Certara USA, Inc. 

NlmeCovariateParameter-class function

<dl><dt>name</dt>
<dd>Name of covariate parameter</dd>
<dt>type</dt>
<dd>Type of covariate parameter: Continuous|Category|Occasion</dd>
<dt>direction</dt>
<dd>Curve fitting method: Forward|Interpolate|Backward</dd>
<dt>isDiagonal</dt>
<dd>Is the structure diagonal (TRUE)| or box (FALSE)</dd>
<dt>centerValue</dt>
<dd>Covariate centering value</dd>
<dt>isPositive</dt>
<dd>Are the covariate values all positive</dd>
<dt>continuousType</dt>
<dd>Type of value to use for the centering value:
CovarNumber|CovarMean|CovarMedian</dd>
<dt>covarEffList</dt>
<dd>List of covariate effects</dd>
<dt>covarItems</dt>
<dd>List of covariate items</dd></dl>

Arguments

NlmeCovariateParameter — NlmeCovariateParameter-class

<dl>

<dt>name</dt>
<dd>Name of covariate parameter</dd>


<dt>type</dt>
<dd>Type of covariate parameter: Continuous|Category|Occasion</dd>


<dt>direction</dt>
<dd>Curve fitting method: Forward|Interpolate|Backward</dd>


<dt>isDiagonal</dt>
<dd>Is the structure diagonal (TRUE)| or box (FALSE)</dd>


<dt>centerValue</dt>
<dd>Covariate centering value</dd>


<dt>isPositive</dt>
<dd>Are the covariate values all positive</dd>


<dt>continuousType</dt>
<dd>Type of value to use for the centering value:
CovarNumber|CovarMean|CovarMedian</dd>


<dt>covarEffList</dt>
<dd>List of covariate effects</dd>


<dt>covarItems</dt>
<dd>List of covariate items</dd>

</dl>

NlmeCovariateParameter-class: NlmeCovariateParameter

Description

Arguments