NlmeDataset-class

NlmeDataset

Class represents an NLME dataset object

internal

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
modeling. The package provides access to the same advanced Maximum Likelihood
algorithms used by the NLME-Engine in the Phoenix platform. These tools support
a range of analyses, from parametric methods to individual and pooled data, and
support integrated use within the Pirana pharmacometric workbench
<doi:10.1002/psp4.70067>. Execution is supported both locally or on
remote machines.

James Craig

Certara.RsNLME

Pharmacometric Modeling

Michael Tomashevskiy

Vitalii Nazarov

Shuhua Hu

Soltanshahi Fred

Certara USA, Inc. 

NlmeDataset-class function

<dl><dt>dataFile</dt>
<dd>Subject datafile</dd>
<dt>colDefFile</dt>
<dd>Datafile to model mapping file</dd>
<dt>modelFile</dt>
<dd>PML model file</dd>
<dt>estimatesDefFile</dt>
<dd>Initial estimates mapping file</dd>
<dt>estimatesDataFile</dt>
<dd>Initial estimates values</dd>
<dt>doseDefFile</dt>
<dd>Dose column definition file</dd>
<dt>doseDataFile</dt>
<dd>Dose datafile</dd>
<dt>ranEffectDefFile</dt>
<dd>Random effects column definition file</dd>
<dt>ranEffectDataFile</dt>
<dd>Random effects data file</dd>
<dt>predoutFilename</dt>
<dd>Name of predcheck output file</dd>
<dt>phoenixSourceDir</dt>
<dd>Directory containing phoenix generated files</dd>
<dt>workingDir</dt>
<dd>Directory containing datafiles(default cwd)</dd></dl>

Arguments

NLME dataset object — NlmeDataset-class

<dl>

<dt>dataFile</dt>
<dd>Subject datafile</dd>


<dt>colDefFile</dt>
<dd>Datafile to model mapping file</dd>


<dt>modelFile</dt>
<dd>PML model file</dd>


<dt>estimatesDefFile</dt>
<dd>Initial estimates mapping file</dd>


<dt>estimatesDataFile</dt>
<dd>Initial estimates values</dd>


<dt>doseDefFile</dt>
<dd>Dose column definition file</dd>


<dt>doseDataFile</dt>
<dd>Dose datafile</dd>


<dt>ranEffectDefFile</dt>
<dd>Random effects column definition file</dd>


<dt>ranEffectDataFile</dt>
<dd>Random effects data file</dd>


<dt>predoutFilename</dt>
<dd>Name of predcheck output file</dd>


<dt>phoenixSourceDir</dt>
<dd>Directory containing phoenix generated files</dd>


<dt>workingDir</dt>
<dd>Directory containing datafiles(default cwd)</dd>

</dl>

NlmeDataset-class: NLME dataset object

Description

Arguments

Examples