NlmeIndirectParameters-class

NlmeIndirectParameters

Class represents an NLME/PML Indirect PD model parameters

internal

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
modeling. The package provides access to the same advanced Maximum Likelihood
algorithms used by the NLME-Engine in the Phoenix platform. These tools support
a range of analyses, from parametric methods to individual and pooled data, and
support integrated use within the Pirana pharmacometric workbench
<doi:10.1002/psp4.70067>. Execution is supported both locally or on
remote machines.

James Craig

Certara.RsNLME

Pharmacometric Modeling

Michael Tomashevskiy

Vitalii Nazarov

Shuhua Hu

Soltanshahi Fred

Certara USA, Inc. 

NlmeIndirectParameters-class function

<dl><dt>type</dt>
<dd>Indirect model type</dd>
<dt>hasEffectsCompartment</dt>
<dd>Is there data available for an effects compartment?</dd>
<dt>isBuildup</dt>
<dd>Is the response formation (TRUE) or
degradation (FALSE) concentration dependent?</dd>
<dt>isExponent</dt>
<dd>Is there an exponent in the effect statement?</dd>
<dt>frozen</dt>
<dd>Freeze standard deviation to prevent estimation
of the PK part of the model</dd></dl>

Arguments

Class represents an NLME/PML Indirect PD model parameters — NlmeIndirectParameters-class

<dl>

<dt>type</dt>
<dd>Indirect model type</dd>


<dt>hasEffectsCompartment</dt>
<dd>Is there data available for an effects compartment?</dd>


<dt>isBuildup</dt>
<dd>Is the response formation (TRUE) or
degradation (FALSE) concentration dependent?</dd>


<dt>isExponent</dt>
<dd>Is there an exponent in the effect statement?</dd>


<dt>frozen</dt>
<dd>Freeze standard deviation to prevent estimation
of the PK part of the model</dd>

</dl>

NlmeIndirectParameters-class: Class represents an NLME/PML Indirect PD model parameters

Description

Arguments