NlmePkParameters-class

NlmePkParameters

Class represents an NLME/PML PK model parameters

internal

Facilitate Pharmacokinetic (PK) and Pharmacodynamic (PD) modeling
and simulation with powerful tools for Nonlinear Mixed-Effects (NLME)
modeling. The package provides access to the same advanced Maximum Likelihood
algorithms used by the NLME-Engine in the Phoenix platform. These tools support
a range of analyses, from parametric methods to individual and pooled data, and
support integrated use within the Pirana pharmacometric workbench
<doi:10.1002/psp4.70067>. Execution is supported both locally or on
remote machines.

James Craig

Certara.RsNLME

Pharmacometric Modeling

Michael Tomashevskiy

Vitalii Nazarov

Shuhua Hu

Soltanshahi Fred

Certara USA, Inc. 

NlmePkParameters-class function

<dl><dt>parameterization</dt>
<dd>Taken from NlmeModelParameterization</dd>
<dt>absorption</dt>
<dd>Taken from NlmeModelAbsorption</dd>
<dt>numCompartments</dt>
<dd>Number of compartments</dd>
<dt>isTlag</dt>
<dd>Does dose have a time lag?</dd>
<dt>hasEliminationComp</dt>
<dd>Is there data available for an elimination compartment?</dd>
<dt>isFractionExcreted</dt>
<dd>Does compartment include a fraction excreted parameter?</dd>
<dt>isSaturating</dt>
<dd>Is the elimination rate equal to the absorption rate?</dd>
<dt>infusionAllowed</dt>
<dd>Is infusion allowed?</dd>
<dt>isDuration</dt>
<dd>Is duration of infusion measured (TRUE) or rate (FALSE)?</dd>
<dt>isSequential</dt>
<dd>Is model part of a PK/PD model that is being fitted sequentially?</dd>
<dt>isClosedForm</dt>
<dd>Is model closed-form algebraic (TRUE) or differential equation (FALSE)?</dd></dl>

Arguments

Class represents an NLME/PML PK model parameters — NlmePkParameters-class

<dl>

<dt>parameterization</dt>
<dd>Taken from NlmeModelParameterization</dd>


<dt>absorption</dt>
<dd>Taken from NlmeModelAbsorption</dd>


<dt>numCompartments</dt>
<dd>Number of compartments</dd>


<dt>isTlag</dt>
<dd>Does dose have a time lag?</dd>


<dt>hasEliminationComp</dt>
<dd>Is there data available for an elimination compartment?</dd>


<dt>isFractionExcreted</dt>
<dd>Does compartment include a fraction excreted parameter?</dd>


<dt>isSaturating</dt>
<dd>Is the elimination rate equal to the absorption rate?</dd>


<dt>infusionAllowed</dt>
<dd>Is infusion allowed?</dd>


<dt>isDuration</dt>
<dd>Is duration of infusion measured (TRUE) or rate (FALSE)?</dd>


<dt>isSequential</dt>
<dd>Is model part of a PK/PD model that is being fitted sequentially?</dd>


<dt>isClosedForm</dt>
<dd>Is model closed-form algebraic (TRUE) or differential equation (FALSE)?</dd>

</dl>

NlmePkParameters-class: Class represents an NLME/PML PK model parameters

Description

Arguments